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Biotin-conjugated anti-Dxd mAb

Background

Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor. Dxd is cytotoxic to human cancer

cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM, but the control

IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression).

Biotin-anti-DXD-antibody is a conjugation product of Biotin and anti-DXD-antibody. It can be used in PK, PD

analysis and ELISA.

Specificity: Specifically recognizes the target-DXD

Source: Mouse, Monoclonal Clone #13

Isotype: IgG1

Conjugation: Biotin

Concentration: 1.0 mg/ml

Tested applications: ELISA

Recommended dilution: 1:1000 - 1:5000(optimal dilutions should be determined by the end use.)

Storage Buffer: PBS Buffer, pH7.4

Storage: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Stable for 2

years from date of receipt. Aliquot to avoid repeated freezing and thawing.

* Please note: FOR RESEARCH USE ONLY

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